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KMID : 0359819960250030556
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Journal of Korean Neurosurgical Society
1996 Volume.25 No. 3 p.556 ~ p.561
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Treatment of Hypothalamic Hamartoma
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Abstract
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This study presents seven patients with hypothalamic hamartomas diagnosed on the basis of MRl. Histological confirmation was performed in one patient who underwent surgery. Four patients presented with epilepsy. including gelastic seizures. Other
symptoms were behavior abnormalities in 3 patients and precocious puberty in 4 patients. We classify hypothalamic hamartomas into four subgroups according to MRl finding : Types la lesions were less than 10mm in diameter and pedunculaedly
attached
to
tuber cinereum of hypotnalamus without hypothalamic displacement. Type lb lesions less than 10mm and mamillary body. Type lla lesions were more than 10mm in diamenter and sessilely attached to hypothalamus with slight hypothalmic displacement and
Type
llb lesions more than 10mm and with marked displacement of hypothalamus. We could achieve good result with surgical resection in one patient with Type llb hamartoma associated with gelastic seizure that was unresponsive to medical treatment. We
performed gamma knife radiosurgery in three patients with gelastic seizure (2 patients with Type lla and 1 patient with Type llb) and three patients with precocious puberty (2 patients with Type la and patient with Type lb). The authors propose
direct
surgery as a treatment for this progressive syndrome and gamma knife radiosurgerv as alternative treatment for nigh risk patients.
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KEYWORD
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